...drugs against coronavirus infection,Scientific Data - X-MOL

来自 : www.x-mol.com/paper/1349467522 发布时间：2021-03-24

Our systematic literature collection and annotation identified 106 chemical drugs and 31 antibodies effective against the infection of at least one human coronavirus (including SARS-CoV, SAR-CoV-2, and MERS-CoV) in vitro or in vivo in an experimental or clinical setting. A total of 163 drug protein targets were identified, and 125 biological processes involving the drug targets were significantly enriched based on a Gene Ontology (GO) enrichment analysis. The Coronavirus Infectious Disease Ontology (CIDO) was used as an ontological platform to represent the anti-coronaviral drugs, chemical compounds, drug targets, biological processes, viruses, and the relations among these entities. In addition to new term generation, CIDO also adopted various terms from existing ontologies and developed new relations and axioms to semantically represent our annotated knowledge. The CIDO knowledgebase was systematically analyzed for scientific insights. To support rational drug design, a “Host-coronavirus interaction (HCI) checkpoint cocktail” strategy was proposed to interrupt the important checkpoints in the dynamic HCI network, and ontologies would greatly support the design process with interoperable knowledge representation and reasoning.

中文翻译：

2021年1月13日Our systematic literature collection and annotation identified 106 chemical drugs and 31 antibodies effective against the infection of at le...Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection; Yingtong Liu, Junguk Hur, Wallace K. B. Chan, Zhigang Wang, Jiangan Xie, Duxin Sun, Samuel Handelman, Jonathan Sexton, Hong Yu, Yongqun He; Sci. Data; Scientific Data; X-MOLOur systematic literature collection and annotation identified 106 chemical drugs and 31 antibodies effective against the infection of at least one human coronavirus (including SARS-CoV, SAR-CoV-2, and MERS-CoV) in vitro or in vivo in an experimental or clinical setting. A total of 163 drug protein targets were identified, and 125 biological processes involving the drug targets were significantly enriched based on a Gene Ontology (GO) enrichment analysis. The Coronavirus Infectious Disease OntolOntological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection,Scientific Data